Frankenstein's Minister
Many years ago, the editor
of this magazine, who was then the editor of the New Republic , coined an
aphorism for political influence peddlers who defended their shady methods on
the grounds that they didn't violate the law. The scandal, he observed, isn't
what's illegal, but what's legal. Since then, politics has stagnated, science
has exploded, and the art of moral rationalization has mutated to suit the new
environment. In this world, the game is redesigning human beings, the stakes
are ownership of the fountain of youth, and the scandal is what passes as
"ethical."
Last
week, Sen. Arlen Specter, R-Pa., and Sen. Tom Harkin, D-Iowa, convened a
hearing to examine the moral implications of two recent experiments.
Researchers funded by one company, Geron, testified that they had taken "stem
cells" from human embryos and fetuses and had grown them into neurons, muscle
cells, and other tissues. Meanwhile, the CEO of another company, Advanced Cell
Technology, testified that by putting the nucleus of an adult human cell into a
cow's gutted egg cell, his researchers had converted it into an embryonic human
cell, which presumably could be manipulated in the same way. "As we learn to
control the pathways that take stem cells down the road to neurons, blood
vessels, and heart cells," Geron's Vice President Dr. Thomas Okarma testified,
"we can immortalize them by telomerase gene transfer, so that sufficient
quantities of these cells can be grown for transplant applications." Old folks'
"degenerating organs" would be repaired "with young, healthy, and fully
functional cells." And one of the first organs to be repaired in this way, the
researchers promised, would be the brain.
All this sounds wonderful. We can cure diseases,
immortalize cells, and theoretically live forever without the nasty old moral
problem of "harvesting" fetuses. But the prospect of a human spare parts
industry modeled on cooking, farming, and car repair raises a new moral
problem. Human ingenuity--a grand synthesis of agriculture, manufacturing, and
information technology--is dissolving human nature.
The ethicists who advise
politicians and biotech firms can't comprehend the gravity of this step. Like
lawyers, they dwell on details instead of the big picture. While taking care
never to cross the line, they ignore anything short of crossing it, and they
don't notice that the line is gradually receding. They look for moral problems
in costs but never in benefits. And they quarrel over yesterday's issues while
being overrun by tomorrow's.
For years,
biotechnology ethics has been mired in the politics of abortion. Since federal
law restricts research on fetal tissue and human embryos, the debate over stem
cells has focused on whether they are embryos and, if not, whether scientists
are killing embryos to get them. The token biotech critic at last week's
hearing, Richard Doerflinger of the National Conference of Catholic Bishops,
ignored the novel implications of the latest experiments, complaining instead
that the researchers had destroyed embryos in the process. Conversely,
pro-biotech witnesses argued that the stem cells in the experiments were only
"pluripotent" (capable of forming many tissues), not "totipotent" (capable of
forming an entire body), and therefore weren't organisms or embryos. "The issue
that we're dealing with," said Harold Varmus, the director of the National
Institutes of Health, "is complying with the law, knowing the legal definition
of an organism."
But this lawyerly parsing misses the larger
moral challenge: The distinction between organisms and nonorganisms is
collapsing. In embryonic development, totipotent cells (ostensibly organisms)
divide into pluripotent cells (ostensibly nonorganisms), which in turn divide
into cells that are "committed" to become specific tissues. The differences in
time and in degree of versatility can be subtle. Moreover, the cow-egg
experiment, like the previous cloning of a sheep, proved that the cycle is
reversible: "Committed" adult cells can be restored to embryonic
totipotency.
The
ethicists who testified at the hearing were obtuse to this conundrum. The
executive director of the National Bioethics Advisory Committee confessed that
in the course of discussing the stem cell experiments, NBAC hadn't got around
to the question of defining an organism. Doerflinger, the Catholic spokesman,
was so intent on asserting the unique personhood of totipotent cells that he
dismissed pluripotent cells, by contrast, as nonorganisms. Rather than confront
the new moral questions raised by stem cell technologies, the witnesses praised
them for abolishing the old moral questions. Banks of stem cells, Varmus
observed, would reduce the need for "fetal donors." (The biotech executives'
comments on "ethics" were even more diversionary. Click for an example.)
The panel's discussion of the cow-egg experiment was
equally shallow. Harkin quoted from a letter in which President Clinton had
said he was "deeply troubled by this news of experiments involving the mingling
of human and nonhuman species." The senators joined Michael West, the CEO who
had supervised the experiment, in debunking this "misinformation" (the cow's
genomic DNA was never mixed with the human DNA) and deriding the half-bovine,
half-human monsters drawn by editorial cartoonists as "science fiction." West
explained that he had used the cow egg only to "reprogram" the human cell,
making it "young again" and restoring its ability to "become any cell type."
The fake issue of mixing species thus obscured the genuine issue of
"reprogramming."
The other
overhyped controversy that distracts ethicists from the real action is cloning.
The notion of replicating whole human beings transfixes biotech alarmists. This
concern, like species mixing, is easily dispelled. "We are not cloning human
beings," West testified at the hearing. Indeed, why manufacture whole people
when there's more money in the parts business? The horror movie
scenario--cloning your whole body, freezing the clone, and "harvesting" its
liver and kidneys when you need them--diverts scrutiny from the real scenario:
"banking" your stem cells and growing them into new organs, including brain
tissue, a la carte.
This erosion of the distinction between whole
humans and their parts--technicians will be able to tweak your cells either
way--brings into question the moral privileges we attribute to whole humans,
such as personhood and bodily integrity. But no one broached these questions at
the hearing. Instead, as with abortion, the panelists praised the new
techniques for solving the old questions. Doerflinger happily argued that by
demonstrating other ways of deriving stem cells, the new experiments had proved
that the cloning of whole embryos could be banned, as Catholic scholars have
proposed, without disrupting biotech research.
Ethicists also have trouble
recognizing the new issues because they're trained to look for moral problems
in technology's costs, not in its benefits. Dr. Arthur Caplan, the only
ethicist at the hearing who betrayed any awareness of the new issues, focused
instead on the morality of "trade-offs." "We should seek to achieve the most
good or benefit, with the least harm and destruction of things that we value,"
he argued. But the benefits of the new technologies--ultimately, immortality
and the rewriting of the recipe for human beings--are precisely what
philosophers ought to ponder. Where are we going? What are we becoming?
The
immediate threat posed by the unraveling of the old physical and moral
distinctions--between human beings and human parts, organisms and nonorganisms,
subjects and objects--is that private interests will come to own the stuff of
which we're made. As the hearing ended, Harkin expressed alarm that biotech
companies were claiming licenses and patents to human stem cells. He said this
concern had to do with the law, "not with ethical and moral implications." But
if ethics is relegated to peripheral and obsolete questions while industry
deconstructs, redesigns, and manufactures human components just like any other
commodity, laws that exempt these components from patenting, licensing, and
other property rights will lose their moral basis. And critics who object that
human life is sacred won't have a leg to stand on.
If you missed the link
about biotech companies' sham "ethics" codes, click .
